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Loss of renal SNX5 results in impaired IDE activity and insulin resistance in mice.
Li F, Yang J, Villar VAM, Asico LD, Ma X, Armando I, Sanada H, Yoneda M, Felder RA, Jose PA, Wang X. Li F, et al. Diabetologia. 2018 Mar;61(3):727-737. doi: 10.1007/s00125-017-4482-1. Epub 2017 Oct 28. Diabetologia. 2018. PMID: 29080975 Free PMC article.
METHODS: The regulation of IDE by SNX5 expressed in the kidney was studied in vitro and in vivo. Snx5 or mock siRNA was added to immortalised hRPTCs (passage <20) in culture or selectively infused, via osmotic mini-pump, into the remnant kidney of u …
METHODS: The regulation of IDE by SNX5 expressed in the kidney was studied in vitro and in vivo. Snx5 or mock siRNA was …
Sorting nexin 5 and dopamine d1 receptor regulate the expression of the insulin receptor in human renal proximal tubule cells.
Li F, Yang J, Jones JE, Villar VA, Yu P, Armando I, Felder RA, Jose PA. Li F, et al. Endocrinology. 2015 Jun;156(6):2211-21. doi: 10.1210/en.2014-1638. Epub 2015 Mar 31. Endocrinology. 2015. PMID: 25825816 Free PMC article.
SNX5 is important in the resensitization of the dopamine D1-like receptor (D1R). ...To evaluate the role of SNX5 and D1R on IR signaling, we silenced via RNA interference the endogenous expression of SNX5 or the D1R gene DRD1 in hRPTCs. ...
SNX5 is important in the resensitization of the dopamine D1-like receptor (D1R). ...To evaluate the role of SNX5 and D1R on IR …